The SAS System 10:25 Sunday, July 13, 2008 1 The Mixed Procedure Model Information Data Set WORK.FEV1UNI Dependent Variable fev1 Covariance Structure Compound Symmetry Subject Effect patient(drug) Estimation Method REML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values drug 3 a c p patient 24 201 202 203 204 205 206 207 208 209 210 211 212 214 215 216 217 218 219 220 221 222 223 224 232 hour 8 1 2 3 4 5 6 7 8 Dimensions Covariance Parameters 2 Columns in X 36 Columns in Z 0 Subjects 72 Max Obs Per Subject 8 Number of Observations Number of Observations Read 576 Number of Observations Used 576 Number of Observations Not Used 0 Iteration History Iteration Evaluations -2 Res Log Like Criterion 0 1 1263.95663130 1 1 396.55067972 0.00000000 Convergence criteria met. The SAS System 10:25 Sunday, July 13, 2008 2 The Mixed Procedure Estimated R Matrix for patient(drug) 201 a Row Col1 Col2 Col3 Col4 Col5 Col6 Col7 1 0.5034 0.4403 0.4403 0.4403 0.4403 0.4403 0.4403 2 0.4403 0.5034 0.4403 0.4403 0.4403 0.4403 0.4403 3 0.4403 0.4403 0.5034 0.4403 0.4403 0.4403 0.4403 4 0.4403 0.4403 0.4403 0.5034 0.4403 0.4403 0.4403 5 0.4403 0.4403 0.4403 0.4403 0.5034 0.4403 0.4403 6 0.4403 0.4403 0.4403 0.4403 0.4403 0.5034 0.4403 7 0.4403 0.4403 0.4403 0.4403 0.4403 0.4403 0.5034 8 0.4403 0.4403 0.4403 0.4403 0.4403 0.4403 0.4403 Estimated R Matrix for patient(drug) 201 a Row Col8 1 0.4403 2 0.4403 3 0.4403 4 0.4403 5 0.4403 6 0.4403 7 0.4403 8 0.5034 Estimated R Correlation Matrix for patient(drug) 201 a Row Col1 Col2 Col3 Col4 Col5 Col6 Col7 1 1.0000 0.8746 0.8746 0.8746 0.8746 0.8746 0.8746 2 0.8746 1.0000 0.8746 0.8746 0.8746 0.8746 0.8746 3 0.8746 0.8746 1.0000 0.8746 0.8746 0.8746 0.8746 4 0.8746 0.8746 0.8746 1.0000 0.8746 0.8746 0.8746 Estimated R Correlation Matrix for patient(drug) 201 a Row Col8 1 0.8746 2 0.8746 3 0.8746 4 0.8746 The SAS System 10:25 Sunday, July 13, 2008 3 The Mixed Procedure Estimated R Correlation Matrix for patient(drug) 201 a Row Col1 Col2 Col3 Col4 Col5 Col6 Col7 5 0.8746 0.8746 0.8746 0.8746 1.0000 0.8746 0.8746 6 0.8746 0.8746 0.8746 0.8746 0.8746 1.0000 0.8746 7 0.8746 0.8746 0.8746 0.8746 0.8746 0.8746 1.0000 8 0.8746 0.8746 0.8746 0.8746 0.8746 0.8746 0.8746 Estimated R Correlation Matrix for patient(drug) 201 a Row Col8 5 0.8746 6 0.8746 7 0.8746 8 1.0000 Covariance Parameter Estimates Cov Parm Subject Estimate CS patient(drug) 0.4403 Residual 0.06313 Fit Statistics -2 Res Log Likelihood 396.6 AIC (smaller is better) 400.6 AICC (smaller is better) 400.6 BIC (smaller is better) 405.1 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 1 867.41 <.0001 The SAS System 10:25 Sunday, July 13, 2008 4 The Mixed Procedure Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F drug 2 69 3.60 0.0327 hour 7 483 38.86 <.0001 drug*hour 14 483 7.11 <.0001