The SAS System                               16:07 Sunday, July 13, 2008   1

The Mixed Procedure

                  Model Information

Data Set                     WORK.HR                  
Dependent Variable           HR                       
Covariance Structures        Variance Components,     
                             Spatial Power            
Subject Effects              patient, patient         
Estimation Method            REML                     
Residual Variance Method     Profile                  
Fixed Effects SE Method      Model-Based              
Degrees of Freedom Method    Containment              


              Class Level Information
 
Class      Levels    Values

drug            3    p b a                         
hours           5    0.0002777778 0.0833333333 0.25
                     0.5 1                         
patient        24    201 202 203 204 205 206 207   
                     208 209 210 211 212 214 215   
                     216 217 218 219 220 221 222   
                     223 224 232                   


            Dimensions

Covariance Parameters             3
Columns in X                     25
Columns in Z Per Subject          1
Subjects                         24
Max Obs Per Subject               5


          Number of Observations

Number of Observations Read             120
Number of Observations Used             120
Number of Observations Not Used           0


                     Iteration History
 
Iteration    Evaluations    -2 Res Log Like       Criterion

        0              1       782.92630122                
        1              2       785.80472075     23.79484703
        2              3       761.38168003      0.05140615
        3              1       740.76130248      0.04499968
        4              3       732.30736270       .        
        5              5       730.87577186      0.02818768
        6              5       730.13736066      0.00636764
        7              1       727.99163232      0.00212044
        8              1       727.30396307      0.00047687
The SAS System                               16:07 Sunday, July 13, 2008   2

The Mixed Procedure

                     Iteration History
 
Iteration    Evaluations    -2 Res Log Like       Criterion

        9              1       727.15923992      0.00002801
       10              1       727.15144263      0.00000013
       11              1       727.15140875      0.00000000


                   Convergence criteria met.                    


               Estimated R Matrix for patient 201
 
 Row        Col1        Col2        Col3        Col4        Col5

   1     36.6559     21.7844      7.6672      1.6010     0.06980
   2     21.7844     36.6559     12.9014      2.6939      0.1175
   3      7.6672     12.9014     36.6559      7.6539      0.3337
   4      1.6010      2.6939      7.6539     36.6559      1.5982
   5     0.06980      0.1175      0.3337      1.5982     36.6559


         Estimated R Correlation Matrix for patient 201
 
 Row        Col1        Col2        Col3        Col4        Col5

   1      1.0000      0.5943      0.2092     0.04368    0.001904
   2      0.5943      1.0000      0.3520     0.07349    0.003204
   3      0.2092      0.3520      1.0000      0.2088    0.009104
   4     0.04368     0.07349      0.2088      1.0000     0.04360
   5    0.001904    0.003204    0.009104     0.04360      1.0000


               Estimated V Matrix for patient 201
 
 Row        Col1        Col2        Col3        Col4        Col5

   1     74.7206     59.8491     45.7319     39.6656     38.1345
   2     59.8491     74.7206     50.9661     40.7585     38.1821
   3     45.7319     50.9661     74.7206     45.7186     38.3984
   4     39.6656     40.7585     45.7186     74.7206     39.6628
   5     38.1345     38.1821     38.3984     39.6628     74.7206


 Covariance Parameter Estimates
 
Cov Parm      Subject    Estimate

Intercept     patient     38.0647
SP(POW)       patient    0.001901
Residual                  36.6559
The SAS System                               16:07 Sunday, July 13, 2008   3

The Mixed Procedure

           Fit Statistics

-2 Res Log Likelihood           727.2
AIC (smaller is better)         733.2
AICC (smaller is better)        733.4
BIC (smaller is better)         736.7


         Type 3 Tests of Fixed Effects
 
               Num     Den
Effect          DF      DF    F Value    Pr > F

drug             2      84       1.47    0.2349
hours            4      84       5.17    0.0009
drug*hours       8      84       1.07    0.3922
basehr           1      84      23.36    <.0001
The SAS System                               16:07 Sunday, July 13, 2008   4

              Plot of meanhr*minute.  Symbol is value of drug.

meanhr |
       |
    88 +
       |
       |
       |
       |      b
    86 +
       |
       |b
       |                                 b
       |
    84 +
       |a                b
       |
       |
       |
    82 +
       |
       |
       |
       |      p
    80 +                                 p
       |      a
       |p
       |
       |                 p                                                b
    78 +
       |
       |
       |                 a               a
       |                                                                  p
    76 +
       |
       |
       |
       |
    74 +
       |
       |
       |
       |
    72 +
       |
       |                                                                  a
       |
       |
    70 +
       |
       -+----------+----------+----------+----------+----------+----------+-
        0         10         20         30         40         50         60

                                       minute