Devan V. Mehrotra
Ph.D.
Merck Research Labs
Clinical Biostatistics, UN-A102
785 Jolly Rd, Bldg C
Blue Bell, PA 19422
E-mail Address: devan_mehrotra@merck.com
Web Address: None
Phone: (610) 397-2621
Fax: (610) 397-7105
Address: Merck Research Labs
Clinical Biostatistics, UN-A102
785 Jolly Rd, Bldg C
Blue Bell, PA 19422

Title: Stratification Issues for a Trial with a Binary Endpoint
Duration: 1 hour
Audience: Graduate students and faculty
Abstract: This talk addresses three important issues for a stratified comparative trial with a binary endpoint. First, how to define the overall treatment effect parameter. Second, how to (and how not to) test for a treatment by stratum interaction (TxS). Finally, when, why and how the outcome of the TxS test may influence the weights assigned to each stratum for estimating the overall treatment effect. Numerical examples are provided to reinforce the key points.
Honorarium: None