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Devan V. Mehrotra Ph.D. Merck Research Labs Clinical Biostatistics, UN-A102 785 Jolly Rd, Bldg C Blue Bell, PA 19422 |
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| E-mail Address: | devan_mehrotra@merck.com |
| Web Address: | None |
| Phone: | (610) 397-2621 |
| Fax: | (610) 397-7105 |
| Address: | Merck Research Labs Clinical Biostatistics, UN-A102 785 Jolly Rd, Bldg C Blue Bell, PA 19422 |
| Title: | Relative Risk Estimation and Inference Using a Generalized Logrank Statistic |
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| Duration: | 1 to 1.5 hours |
| Audience: | Graduate students and faculty |
| Abstract: | The standard tool for relative risk estimation and inference is the Cox proportional hazards model. However, the Cox model is inefficient with small samples. We show why this is the case, and propose a simple alternative method of estimation and inference based on a generalized logrank (GLR) statistic. While the GLR and Cox approaches are asymptotically similar, the former is notably more efficient when the sample sizes are small (<100 per group). Numerical examples are provided for illustration. |
| Honorarium: | None |