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Biostatistician III
Duke Human Vaccine Institute

Company Information: About DHVI
The Duke Human Vaccine Institute (DHVI) has established a place of national and international leadership in the fight against the major infectious diseases. Our investigators understand the power and opportunity of the team approach and are poised to make major new contributions to global health challenges. Programs led by the DHVI are described below.
The External Quality Assurance Program Oversight Laboratory (EQAPOL) is a National Institute of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID)-Division of AIDS (DAIDS) funded resource located at Duke Human Vaccine Institute’s (DHVI) Immunology and Virology Quality Assessment Center (IVQAC) to support the development, implementation and oversight of external quality assurance programs that monitor laboratories involved in HIV/AIDS research and vaccine trials around the world.
The IVQAC is a resource designed to help domestic and international immunologists evaluate and enhance the integrity and comparability of immunological laboratory determinations performed on patients enrolled in multi-site HIV/AIDS therapeutic, vaccine and prevention investigations.

The Clinical Immunization Safety Assessment (CISA) Project is a Centers for Disease Control and Prevention (CDC) network aimed at assessing vaccine safety in special populations. Duke investigators conducts a number of studies to assess vaccine safety in special populations and to evaluate potential strategies to prevent AEFI. The Duke Human Vaccine Institute (DHVI) plays a critical role by providing the necessary infrastructure to conduct laboratory assessments for Duke CISA activities.

The Center for HIV/AIDS Vaccine Immunology (CHAVI-ID) is currently one of two implementation projects under the Global HIV Vaccine Enterprise, the other being the recently funded Collaboration for AIDS Vaccine Discovery (CAVD) by grants from the Bill and Melinda Gates Foundation. The Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) is a consortium that was established by the National Institute for Allergy and Infectious Diseases (NIAID) to undertake the immunologic research that will tackle the major scientific obstacles in the development of an effective HIV-1 vaccine. The vaccine strategy of the Duke CHAVI-ID is based on identifying and targeting novel HIV-1 vulnerabilities to B, T and NK cell immune responses and using this information to design vaccines that will induce protective immunity at the time and location of HIV-1 transmission.

Position Title: Biostatistician III

Duties and Responsibilities: Occupational Summary
The Biostatistician III will be lead statistician for the IQA Program. This work will include, but not be limited to, managing data from multiple labs, completing data checks, analyses, and report generation within the project deadlines while working independently. The Biostatistician III will perform intermediate and advanced statistical analyses in collaboration with the Biostatistics team and Principle Investigators.

Duties and Responsibilities
• Independently design, document and prepare analysis data sets for the IQA Program as well as prepare quarterly reports describing the statistical methodologies used along with the interpretation of the statistical analysis.
• Learn and apply new statistical methods to the IQA Program as needed.
• Collaborate with IQA program project leaders and develop analysis plans for new research questions that arise.
• Perform data management and data review using SAS and/or R for quarterly querying of labs in the IQA Program.
• Perform data management, analysis data set creation or verification, as well as statistical analysis for the EQAPOL Program and CISA activities.
• Provide statistical input and researches potential statistical methodologies with the Biostatistics group for application in DHVI programs (IQA, EQAPOL, CISA, or CHAVI-ID).
• Write efficient and complex programs in SAS and/or R for the creation of analysis data sets as well as statistical analyses. Research and discover new programming techniques to share with the Biostatistics team.
• Follow all SOPs and relevant guidelines (e.g., ICH, CLSI) for statistical analyses, programming, and statistical assessment of laboratory performance.
• Manage multiple projects and deadlines, as well as provide solid estimates of statistical effort required for a research project. Communicate potential project issues with the lead researcher or Biostatistics team.
• Work with lead researchers on study design and the preparation of sample size and power calculations. Provide the lead researcher with final data tables, figures, and listings and interpretation of the results.
• Develop and present research for meetings or conferences as well as write statistical method sections for manuscripts and grant applications.
• Perform data management, statistical tasks or other duties as assigned.

Position Qualifications: Education and Experience
• Position requires a minimum of a Doctoral degree in biostatistics or related field and no relevant experience, or a Master’s degree in biostatistics or related field and 2 years relevant experience, or a Bachelor’s degree in biostatistics or related field and 4 years relevant experience.
• Experience with R and SAS programming.
• Experience with biological research, assay analysis, development and assessment.
• Good written and oral communication skills.

Salary Range:



Application Information: Candidates should apply to requisition 401355676 on the Duke employment website and send a cover letter and current CV to:

Duke Human Vaccine Institute
(Please reference “BIOII” in subject line of email)

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender expression, gender identity, national origin, race, religion, sexual orientation, or veteran status.

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